Revista Cubana de Pediatría

Introduction of pneumococcal vaccination, a joint project of Biotechnology and the Cuban Health Care System

Invasive pneumococcal disease in children with communtiy-acquired severe pneumonia

Clinical progression, microbiological isolate and cost of antimicrobials in the community-acquired complicated pneumonia

Behavior of pneumococcal disease at "Juan Manuel Marquez" pediatric hospital

Therapeutic effectiveness of amoxicillin for treatment of community-acquired pneumonia at pediatric ages

Epidemiology of pneumococcal meningitis in Cuban children younger than 6 years

Clinical and imaging characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae

Bacterial meningoencephalitis in a population younger than 18 years

Nasopharyngeal colonization of pneumococci in the Cuban infant population, prevalence study-based evidence

Child hospitalizations for Streptococcus pneumoniae-associated diseases in Cienfuegos province

Burden of hospital admissions and population for the community-acquired pneumonias in children aged less than 5 years

Pneumococcal disease and related infections seen in pediatric patients discharged from the Southern Pediatric Hospital of Santiago de Cuba province

Invasive pneumococcal disease in hospitalized children aged less than 6 years

Pneumococcal disease seen in children younger than 5 years in "Juan de la Cruz Martinez Maceira" Northern Pediatric Hospital of Santiago de Cuba province

Surveillance of patients with pneumococcal disease and admitted to "Antonio María Beguez César" Southern Teaching Pediatric Hospital

Hospitalizations for community-acquired pneumonia

Streptococcus pneumoniae serotypes responsible for invasive disease affecting Cuban children

New Cuban pneumococcal vaccine, from available scientific evidence to the strategy of clinical and impact evaluation

Este trabajo resume el marco de evidencias que sustenta el actual uso de las vacunas antineumocócicas conjugadas en términos de seguridad, inmunogenicidad, eficacia y efectividad. Presenta una nueva alternativa para prevenir la enfermedad neumocócica en la población infantil basada en el nuevo candidato vacunal cubano contra neumococo. Expone los principios básicos que definen la estrategia para su introducción en Cuba, y los avances derivados de la aplicación de un modelo integrado para la evaluación clínica e impacto en salud en fase de implementación, el cual busca proveer las evidencias científicas que soporten la decisión del sistema nacional de salud para su introducción en el esquema nacional de inmunizaciones y su posterior comercialización en la era de las vacunas conjugadas antineumocócicas. Se presentan los resultados preliminares de estudios concluidos, y se elaboran conclusiones sobre los aportes científicos y prácticos de la estrategia de implementación y el modelo de evaluación para la nueva vacuna.

This paper summarized the group of evidence that supports the present use of the pneumococcal conjugate vaccines in terms of safety, immunogenicity, efficacy and effectiveness. It offers a new alternative to prevent the pneumococcal disease in the infant population on the basis of a new Cuban vaccinal candidate against pneumococci. It set out the basic principles that define the strategy for the introduction of this vaccine in Cuba and the advances resulting from the use of an integrated model for the clinical evaluation and the impact on health, in its implementation phase, which seeks to provide the scientific evidence backing up the decision of the national health care system to introduce this vaccine in the national immunization schedule and its further commercialization in the era of pneumococcal conjugate vaccines. Preliminary results of finished studies were presented and the conclusions on the scientific and practical contributions of the strategy of implementation and the evaluation model for the new vaccine were worked out.