LAVAUT SANCHEZ, Kalia    PAVON MORAN, Valia. Clonal evolution in chronic myeloid leukemia. []. , 29, 2, pp. 114-118. ISSN 0864-0289.

Clonal evolution in chronic myeloid leukemia is defined as the presence of a variety of additional, nonrandom chromosomal abnormalities besides the Philadelfia chromosome. It occurs in approximately 30 % of patients in accelerated phase and 80 % of patients in blastic phase. It is considered a criterion for accelerated phase. Although it is associated with a poor prognosis, its significance is controversial. It depends on the specific cytogenetic abnormality, its frequency in karyotype study, the association with other progression clinical and cytogenetic alterations, its relationship with the time of appearance during the course of the disease and the therapy used.

: clonal evolution; chronic myeloid leucemia; Philadelphia chromosome; imatinib.