MARTI-CABRERA, Miguel et al. Proton pump inhibitors and calcium homeostasis. []. , 32, 4, pp. 431-444. ISSN 0864-0300.

Background: the relationship between proton pump inhibitors (PPI) and the risk of osteoporosis and bone fractures is a topic of great interest in recent medical literature. PPI are first choice drugs for diseases evolving with an increase in acid secretion. Due to their growing prescription, their potential toxicity is periodically verified. Objectives: the present review analyzes the physiopharmacological bases and limited clinical evidence of a potential relationship between continued administration of PPIs and the appearance of osteoporosis and bone fractures. Both conditions are related to calcium homeostasis, and their relevance in elderly patients is high, due to their poor general prognosis and disabling effects.

: PPI; fractures; osteoporosis; calcium; toxicity; acid secretion inhibition.

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