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Asociación de la severidad de la periodontitis con niveles de cotinina y Porphyromonas gingivalis


 
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Revista Archivo Médico de Camagüey

 ISSN 1025-0255

ARDILA MEDINA, Carlos Martín; GUZMAN ZULUAGA, Isabel Cristina    VELEZ ECHEVERRI, Maria Adelaida. Association between the severity of periodontitis with cotinine levels and Porphyromonas gingivalis. []. , 18, 4, pp. 391-400. ISSN 1025-0255.

Background: cotinine increases the effects of the toxins produced by periodontopathogens and it has been observed that the smoking habit alters the humoral response and decreases the effectiveness of Porphyromonas gingivalis. Objective: to investigate the association between the cotinine levels and the severity and extent of periodontitis; as well as between the cotinine levels and the presence of Porphyromonas gingivalis. Method: in the present cross-sectional study, the universe was composed of 108 individuals. The periodontal parameters were measured in six sites per tooth in all the teeth; the third molar was excluded. Some samples of Porphyromonas gingivalis in the periodontal pocket were taken. Results: when comparing smokers and non-smokers, differences statistically significant in the probing depth and in the clinical attachment level were observed with worse periodontal conditions in smokers (p < 0.001). P. gingivalis was found in 64 individuals (59, 3 %) and cotinine levels ≥ 10ng/ml in 25 patients (23, 1 %). A statistically significant difference was observed between advanced periodontitis and cotinine levels ≥10ng/ml (p < 0.001), and between cotinine levels ≥ 10ng/ml and the presence of P. gingivalis(p < 0.05). Conclusions: cotinine levels found in serum ≥ 10ng/ml were associated with deeper periodontal pockets and a greater loss of insertion; an association between cotinine and P. gingivalis was also found with worse periodontal clinical conditions in smokers.

: SMOKING; COTININE; PERIODONTITIS; ADULT; OBSERVATIONAL STUDY.

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