Abstract

CESPEDES VALCARCEL, Alfredo J.; DE LA PAZ NARANJO, José; SEBAZCO PERNAS, Caridad  and  MARTINEZ TORRES, María del C.. Effects of Melissa officinalis L. tincture on isolated ileum and in diarrhea model. Rev Cub Med Mil [online]. 1996, vol.25, n.1, pp. 0-0. ISSN 1561-3046.

Two studies were carried out: one in vitro in the guinea pig isolated ileum, and the other in vivo, in a diarrhea model in rats, with the purpose of confirming the antispasmodic action of a 20 % Melissa officinalis L. tincture. In the in vitro model, it was found that the 0,084; 0,169 and 0,338 mg/mL doses of nutritious solution provoke a significant decrease (p < 0,05) of the acetylcholine induced contraction (10 mg/mL). In the in vivo study, it was determined that 16,9; 33,8 and 67,6 mg/kg of weight doses decreased the time of appearance of the first diarrhea, and its frequency. In both models the effect was dependent on the doses. The tincture had an antispasmodic effect in the two models used, and an antidiarrheic action on the in vivo model.

Keywords : MELISSA OFFICINALIS L. [therapeutic use]; ILEUM; DIARRHEA [drug therapy]; GUINEA PIGS; RATS, INBRED BB.