Mi SciELO
Servicios Personalizados
Articulo
Indicadores
- Citado por SciELO
Links relacionados
- Similares en SciELO
Compartir
Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
Resumen
PEREDA RODRIGUEZ, Diana; PEREZ SOUTO, Néstor; MARTINEZ MIRANDA, Lisette y CHANG VALDES, Aleyda. Evaluación comparativa de la liberación in vitro de Metildopa de producción nacional contra Aldomet®. Rev Cubana Farm [online]. 2001, vol.35, n.1, pp. 13-17. ISSN 1561-2988.
A comparative study was made between the dissolution profiles of 3 lots of Aldometâ (Merck, Sharp & Dohme), a leading drug of the methyldopa active principle (DCI), and of 3 batches of methyldopa 250 mg of national production. The spectrophotometric method was used for the quantification of the active principle in the different batches, which fulfilled the criteria of the Food and Drug Administration (FDA) for the in vitro equivalency studies. The best adjustment to common models for dissolution profiles was determined among the data obtained by using the CurveExpert program.
Palabras clave : COMPARATIVE STUDY; DRUG SCREENING; METHYILDOPA [pharmacokinetics]; CHEMISTRY, PHARMACEUTICAL [methods]; TECHNOLOGY, PHARMACEUTICAL; SPECTROPHOTOMETRY [methods]; THERAPEUTIC EQUIVALENCY.