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Revista Archivo Médico de Camagüey
versión On-line ISSN 1025-0255
Resumen
MORENO-LAGUARDA, Yaimé; LAGUNA-SALVIA, Leonardo; LARQUIN-COMET, José Ignacio y LEON-RAMENTOL, Cira Cecilia. Fludarabine in the treatment of follicular non-Hodgkin lymphoma. AMC [online]. 2020, vol.24, n.6 Epub 01-Dic-2020. ISSN 1025-0255.
Background:
follicular non-Hodgkin's lymphoma occupies the second place among non-Hodgkin's lymphomas of line B, they are characterized by a pattern of continuous remissions and relapses. Fludarabine constitutes a treatment option for the same as it achieves a rapid remission, with a decrease in the percentage of relapse.
Objective:
to evaluate fludarabine as a rescue treatment for follicular non-Hodgkin lymphoma.
Methods:
a concurrent prospective longitudinal, analytical, observational cohort study was conducted. The study universe was made up of patients who attended the Hematology consultation with a diagnosis of follicular non-Hodgkin's lymphoma and consisted of 63 patients, of which 21 were selected by intentional non-probabilistic sampling who received treatment with fludarabine, made up a cohort of exposed, these were compared with 42 patients with similar characteristics who received other poly-chemotherapy regimens that did not include fludarabine and they constituted the unexposed cohort.
Results:
the number of male patients over 50 years of age, belonging to Cotswold stage IV, and those with a low-intermediate risk of relapse was greater. The disease-free survival time was longer in those treated with fludarabine, who had fewer complications.
Conclusions:
in patients treated with fludarabine as rescue treatment for follicular lymphoma, the disease-free survival time was longer and there were fewer complications, which show its usefulness as a first-line treatment in the absence of rituximab.
Palabras clave : LYMPHOMA, NON-HODGKIN/drug therapy; LYMPHOMA, NON-HODGKIN/therapy; LYMPHOMA, FOLLICULAR/diagnosis; RECURRENCE; OBSERVATIONAL STUDY.