Resumen

GONZALEZ SANTISTEBAN, Álvaro Guillermo; LARRONDO MUGUERCIA, Hilev de las Mercedes  y  PEREZ MESA, Yanet. Epidermal toxic necrolysis in intensive care. Rev cubana med [online]. 2020, vol.59, n.4  Epub 15-Nov-2020. ISSN 1561-302X.

Two patients admitted to a multipurpose intensive care ward were studied. They showed epidemic toxic necrolysis (NTE), a rare complication that has an incidence of 1 to 4 cases per million inhabitants. Drugs were the cause of the disease in these patients and the main drugs involved were amphotericin B and ciprofloxacin. This is the first case of NTE related to the use of Liposomal Amphotericin B reported in Cuba and in the rest of the scientific community, which makes it interesting. The diagnosis was confirmed by skin biopsy, both patients had risk of death, according to the Scorten index, higher than 50%. This research was carried out with the aim of communicating the experience and knowledge to the medical and scientific community in general and to the professionals who work in multipurpose intensive care rooms in particular, since this condition is rare in a multipurpose intensive care room, it is rare in relation to the aforementioned antibiotics, its dramatic clinical status and the torpid evolution of patients.

Palabras clave : epidemic toxic necrolysis; severe skin adverse reactions; intensive care.

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