Introduction:

With the persistence of the current COVID-19 pandemic, it would be assumed that, after two years of evolution, some of its epidemiological characteristics would be completely clarified. However, uncertainties still remain about peculiarities of its transmission that are decisive for the prevention and control of this disease.

Objective:

To examine and update some concepts, evidence and opinions on the transmission of COVID-19 to humans.

Methods:

It was conducted a review of the medical scientific literature on the transmission of SARS-CoV-2, available in PubMed/MEDLINE database, and published between March 2020 and October 2021. Terms related to the transmission of COVID-19 were included in the search. The manual screening of the bibliography of the selected articles allowed identifying additional studies.

Information, analysis and synthesis:

The results and experiences of the research on the transmission of COVID-19 should be considered when implementing more accurate and sustainable sanitary policies and strategies at local and global level. Additional inter-, trans-, and multidisciplinary studies are still needed to better understand the complex interrelation among SARS-CoV-2, the environmental factors, and the susceptible hosts, considering the extraordinary impact of this disease worldwide.

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