Introduction:

Low limbs´ arterial occlusive disease is associated with a high rate of amputations and risk of death. Regarding that, regenerative medicine has proven satisfactory results.

Objective:

To characterize patients with peripheral arterial disease in the low limbs which have been treated with autologous mononuclear cells.

Methods:

It was carried out a prospective longitudinal research in “Arnaldo Milián Castro” Hospital in the period from January, 2015 to December, 2017. From a population of 61 patients, it was intentionally selected by criteria a sample of 52 individuals.

Results:

The average age was 66,9 ± 8,2 and 69,2% were men. The main vascular risk factors were smoking habit, hypercholesterolemia and arterial hypertension. The level of occlusion showed predominance of femoro-popliteal and the bad output tractus was the main cause of non-revascularization. Cell viability was high and it was achieved a significant change in Fontaine stages. The beginning of a clinical improvement happened between the first and the second month in most of the cases. In some patients were open post-surgical possibilities and it was obtained great tisular reperfusion.

Conclusions:

The implant of autologous mononuclear cells in patients with peripheral arterial disease of low limbs represents an useful and effective new strategy of therapeutic angiogenesis which opens new treatment perspectives.

        · resumen en Español     · texto en Español     · Español ( pdf )