Resumen

JAIME FAGUNDO, Juan Carlos; BENCOMO HERNANDEZ, Antonio; SARDUY SAEZ, Sandra  y  LLERENA MORENO, Dunahisy. Haploidentical hematopoietic transplant: a need. Rev Cubana Hematol Inmunol Hemoter [online]. 2017, vol.33, n.3, pp. 27-36. ISSN 1561-2996.

Hematopoietic stem cell transplantation is a potentially curative therapy for patients with various diseases, but only 25- 30% have a compatible donor for human leukocyte antigen. A few years ago it has been developed a transplant with only one identical haplotype; which it is available for most patients, and has been called haploidentical transplantation. There have been attempts to deplete the marrow of T lymphocytes before being infused, mainly due to the presence graft-versus-host disease, and this can lead to primary graft failure and a slow immune recovery. At present, several methods to overcome these drawbacks are made, so this transplantation emerges as an important alternative for those who do not have a fully matched sibling and has the advantage that allows choosing between several candidates and prevents loss of time searching unrelated donor.

Palabras clave : transplantation; haploidentical; haplotype; HLA; KIRs; NIMA.

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