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Revista Cubana de Hematología, Inmunología y Hemoterapia
versión On-line ISSN 1561-2996
Resumen
RODRIGUEZ PRIETO, Luis Dairon et al. Use of platelet lysate in the treatment of epidermal toxic necrolysis: a case presentation. Rev Cubana Hematol Inmunol Hemoter [online]. 2022, vol.38, n.3 Epub 01-Sep-2022. ISSN 1561-2996.
Introduction:
In recent years there has been an extraordinary impulse of regenerative medicine, the use of platelets for this purpose has been used in different medical specialties. The most feared of the dermatological complications is toxic epidermal necrolysis, of which up to 4 cases per million inhabitants occur annually, with a mortality that sometimes reaches up to 70%.
Objective:
To describe the use of platelet lysate as regenerative therapy in the treatment of epidermal toxic necrolysis.
Case presentation:
We present a case of a 53-year-old patient with a pathological history of arterial hypertension, diabetes mellitus, multiple myeloma and chronic renal insufficiency, who was admitted with a diagnosis of community acquired pneumonia and acute chronic renal insufficiency, for which multiple treatments. She began with erythematous, non-pruritic, and then bullous skin lesions that are easily debrided into large areas of denuded skin, scattered throughout the body. A toxic epidermal necrolysis was diagnosed, the usual treatment measures were started and the allogeneic platelet lysate was used topically.
Conclusions:
A favorable response was observed, with cutaneous re-epithelialization of the skin, although the patient's underlying disease and its comorbidities died.
Palabras clave : epidermal toxic necrolysis; regenerative medicine; platelet lysate.