Resumen

LICEA PUIG, Manuel E.; NINA CRUZ, Virginia Romelia  y  DOMINGUEZ ALONSO, Enma. Incipient diabetic nephropathy in type 1 diabetics seen in the Diabetes Care Center and its relation to some clinical and biochemical variables. Rev Cubana Endocrinol [online]. 2006, vol.17, n.3, pp. 0-0. ISSN 1561-2953.

Diabetic nephropathy (DN) is the main cause of death in the persons with type 1 diabetes mellitus. Its prevention and early identification may reduce the morbimortality and improve the quality of life of these persons. The objective of this paper is to determine the frequency of incipient diabetic nephropathy (IDN) in persons with type 1 diabetes mellitus and its connection with some clinical and biochemical variables. Age, sex, weight, height, smoking habit, body mass index, age at diagnosis and time of evolution of type diabetes mellitus, arterial pressure, presence of diabetic retinopathy (DR), fasting glycaemia and glycaemia 2 hours after breakfast (postprandial), glycosilated hemoglobin and albumin urinary excretion (AUE) were the variables studied among 240 persons with type 1 diabetes mellitus seen consecutively at the Diabetes Care Center of the National Institute of Endocrinology, in Havana City. Individuals with clinical DN , non-diabetic nephropathy, or other conditions increasing the AUE, were not included in the study. They were divided into 2 groups: 1) normoalbuminuric (AUE < 20 mg/L/24 h), and II) microalbuminuric or IDN (EUA >20 a < 300 mg/L/24 h). IDN was observed in 38.75 %. It was significantly correlated to age (p< 0,011), the time of evolution of type 1 diabetes mellitus (P< 0,0001), the systolic arterial pressure (p< 0,002), the diastolic arterial pressure (p< 0,002), and to fasting and postprandial glycemia (p<0,0001). It was concluded that IDN was observed in an elevated frequency in subjects with type 1 diabetes mellitus.There are risk factors associated with IDN that may be identified and controlled with an adequate therapy.

Palabras clave : Microalbuminuria; incipient diabetic nephropathy; type 1 diabetes mellitus; arterial hypertension; diabetic retinopathy.