Resumen

FERNANDEZ-BOBEY, Antonio; HERNANDEZ-TORRIENTE, Airovict; GARCIA-PEREZ, Trina Haydee  y  SPENGLER-SALABARRIA, Iraida. Triterpenes with anti-inflammatory activity isolated from the bark of the endemic species Maytenus elaeodendroides, Griseb. Rev Cub Quim [online]. 2020, vol.32, n.1, pp. 61-73.  Epub 26-Feb-2020. ISSN 2224-5421.

Several species from Maytenus genus (Celastraceae family) show anti-inflammatory activity associated to terpene presence. Thus we intend to isolate and characterize triterpenes having potential anti-inflammatory activity from the bark of Maytenus elaeodendroides Griseb. Isolation, purification and structural elucidation of such compounds were achieved by maceration with petroleum ether/diethyl ether (1:1), followed by chromatographic and spectroscopic methods. Anti-inflammatory activity was evaluated by inhibition of Croton oil- induced ear edema in mice. The triterpenes isolated were: 28-hydroxy-3-oxo-20(29)-lupene, 16-hydroxy-3-oxo-20(29)-lupene (herein found for the first time in the Celastraceae family), 3dihydroxy-20(29)-lupene and acid 3-oxo-20(29)-lupene-28-oic. At certain doses the obtained extract showed an anti-inflammatory effect as potent as that exhibited by diclofenac (reference drug). This is the first time it is reported an anti-inflammatory activity for 16-hydroxy-3-oxo-20(29)-lupene. An increase in the anti-inflammatory activity of this last terpene is probably related to the presence of carbonile group in C-3.

Palabras clave : maytenus elaeodendroides; triterpenes; anti-inflammatory activity; Croton oil.

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