Resumen

PANEQUE-SAYAS, Mayelin et al. Protection study of the Labio-Marek vaccine against the JM strain challenge in SPF chickens. Vaccimonitor [online]. 2014, vol.23, n.3, pp. 91-99. ISSN 1025-028X.

Marek's disease is a lymphomatous and neuropathic disease of the domestic chickens caused by herpesvirus. Currently the acute form of the disease, with extended visceral lymphomas, is the most common with an incidence of 10-30%. The objective of the present study was to evaluate the effectiveness of the vaccine Labio-Marek prepared by LABIOFAM against the challenge of the virulent JM strain in specific pathogen free chickens. A dose of the vaccine containing 1000 plate-forming units in 0.2 mL was inoculated in one-day old chickens by subcutaneous route. The chickens were challenged with 10³ TCID₅₀ of the JM strain and observed during 7 weeks to detect neurological signs such as paralysis and others associated with the disease. One group of chickens remained as a control of non-vaccinated chickens, which were challenged, and another group of chickens that was not vaccinated nor challenged. Autopsy was carried out at day 54 after vaccination on chickens that survived the challenge and histological evaluation of the organs was performed. The vaccinated chickens showed no clinical symptoms of the disease and had no microscopic lesions related to Marek's disease virus. However, 71% of non-vaccinated challenged chickens died and 83.87% showed lesions of Marek's disease. It is concluded that the evaluated vaccine can be used for the prevention of Marek's disease in chickens.

Palabras clave : Labio-Marek vaccine; Marek; vaccination.

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