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Revista Cubana de Plantas Medicinales
versión On-line ISSN 1028-4796
Resumen
SALOMON IZQUIERDO, Suslebys; LOPEZ HERNANDEZ, Orestes D y GONZALEZ SANABIA, María Lidia. Development of a technology for obtaining the Momordica charantia L. aqueous extract. Rev Cubana Plant Med [online]. 2011, vol.16, n.4, pp. 304-312. ISSN 1028-4796.
Introduction: Momordica charantia L. aqueous extracts have scientifically-confirmed therapeutical potential, which makes it possible to use it in the treatment of several diseases, particulary diabetes. Obtaining a standardized extract is of great importance to reproduce it at industrial scale and also to obtain a pharmaceutically active ingredient (FAI) for the development of orally administered finished forms. Objectives: to develop a technology at lab scale to obtain standardized aqueous extract from Momordica charantia L. Methods: the study of the operational parameters (vegetal matter-solvent ration and extraction time) was performed in a lab reactor designed according to the dimensions of an industrial reactor, with a 3-level surface design of factorial response (3^2). Results: the studied factors significantly influence the extraction process in which time is the most influential. There exists direct proportion between vegetal matter-solvent ration and the content of extracted solids, being the latter inversely proportionate to the extraction time. The highest content of extracted solids was reached with vegetal matter-solvent ratio of 1:25 and extraction time of 0.5 hours. Conclusions: the operational conditions that support the highest solid extraction in obtaining the aqueous extract at the experimental phase were determined when the vegetal matter-solvent ratio and the extraction time were 1:25 and 0.5 hours respectively.
Palabras clave : aqueous extract; standardized extract; Momordica charantia L; performance.