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Revista Cubana de Pediatría
versión On-line ISSN 1561-3119
Resumen
ACOSTA TORRES, José; PEREZ CUTINO, Maité; RODRIGUEZ PRIETO, Magela y MORALES GONZALEZ, Alejandro. COVID-19 in Pediatrics: clinical and epidemiological aspects, immunopathogenesis, diagnostic and treatment. Rev Cubana Pediatr [online]. 2020, vol.92, suppl.1 Epub 20-Jul-2020. ISSN 1561-3119.
Introduction:
The World Health Organization declared as a pandemic the infection by the coronavirus called SARS-CoV-2 on March 11th, 2020 that emerged in the last days of 2019 in the Chinese province of Wuhan. The disease produced by this coronavirus it is called COVID-19 and it is an entity that has shown low morbidity and mortality in pediatric patients.
Objective:
To examine epidemiological factors, symptomatology, diagnostic and treatment of the disease in pediatric ages.
Methods:
It was reviewed literature using PubMed database to identify articles published until April 30th, 2020, and also reports, series of cases and laboratory data.
Results:
The most frequent onset age was in patients older that 5 years, having 2,5% of seriously ill patients with fever, cough, nasal congestion, dyspnoea, vomiting and diarrhea as the most frequent symptoms. Laboratory data indicated a mean of leukocyte count between 6,1 and 6,8 x 105, lymphopenia with a range between 2,5 and 40%, and an increase of alaniltranferase and creatininfosfoquinase enzymes, in addition to the C reactive protein anti-inflammatory marker with concentrations between 17 and 62,5%. Vertical transmission has not been verified. The most frequently used treatment is Lopinavir/ ritonavir and interferon. Chest X-ray was normal in the 20 to 66 % of the cases. No deaths were recorded in the six series of cases reviewed.
Final considerations:
The infection by SARS-CoV-2 in pediatric ages evolves with a favorable prognosis but more researches on the topic are needed for a best knowledge of this entity.
Palabras clave : coronavirus; COVID-19; SARS-CoV-2; cytokines; retrovirals.