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Revista Cubana de Medicina Tropical
versión On-line ISSN 1561-3054
Resumen
OCHOA AZZE, Rolando Felipe et al. Seguridad e inmunogenicidad de una vacuna de polisacárido Vi de Salmonella typhi en jóvenes cubanos. Rev Cubana Med Trop [online]. 2003, vol.55, n.2, pp. 83-87. ISSN 1561-3054.
A randomized, controlled and double-blind study was conducted in young adults aged 18-20 aimed at evaluating the reactogenecity and immunogenecity of vaz-TyViâ, a vaccine of polyssacharide Vi from Salmonella typhi. They were distributed into 3 groups: immunized with a dose of Vax-TyViâ (Finlay Institute), TYPHIM ViTM (Pasteur-Mérieux) or vax-TETâ (tetanic toxoid). Serum samples were taken before and 21 days after immunization. The immunogenecity was evaluated in 323 volunteers by an indirect ELISA. The seroconversion of those receiving vax-TyViâ was 81.97 % and 65.05 % for TYPHIM ViTM. The postvaccine mean geometric titers were 7.41 U/mL (5.92-9.27 U/mL) and 5.41 U/mL (4.35-6.72 U/mL), respectively. The seroconversion with vax-TETâ was 0 %. The reactogenecity of both polysaccharide vaccines was low. It was concluded that the immunogenecity of vax-TyViâ was not lower than that of TYPHIM ViTM and that its reactogenecity was similar.
Palabras clave : TYPHOID; CLINICAL TRIALS; POLYSACCHARIDES; TYPHOID-PARATYPHOID VACCINES; SALMONELLA TYPHI.