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Revista Cubana de Hematología, Inmunología y Hemoterapia
versión On-line ISSN 1561-2996
Resumen
SANCHEZ SEGURA, Miriam et al. Immunophenotypical characterization of B-cell chronic lymphocytic leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2007, vol.23, n.2, pp. 0-0. ISSN 1561-2996.
The immunophenotypical characterization of bone marrow cells and peripheral blood from 115 patients with B-cell chronic lymphocytic leukemia was performed by an immunocytochemical ultramicromethod at the Institute of Hematology and Immmunology during 13.5 years. The most frequently expressed antigens were: HLA-DR (98 %), CD5 (94 %), CD19 (93 %), CD20 (90 %), CD22 (84 %) and IgS (76 %). The CD-5 antigen was not present in 7 patients. It was found a poor expression of myelomonocytic antigens, such as CD11b (2/27) (7.4 %) and CD11c (5/13) (38.4 %). It was observed a low expression of IgS and of CD22 membrane, since these antigens were only overexpressed in 12.5 % and 32 % of the sick, respectively. There was a predominance in the expression of kappa light chains. The phenotypic behaviour of the patients with B-cell chronic lymphocytic leukemia corresponded with what has been reported by other authors about this entity.
Palabras clave : B-cell chronic lymphocytic leukemia B; immunophenotyping; monoclonal antibodies.