Mi SciELO
Servicios Personalizados
Articulo
Indicadores
- Citado por SciELO
Links relacionados
- Similares en SciELO
Compartir
Revista Cubana de Oftalmología
versión On-line ISSN 1561-3070
Resumen
MOLINET VEGA, Lázara Mairely y PEREZ PACHECO, Arturo Iván. The Epigenetic Role of Ultraviolet Radiation and Oxidative Stress in Cataract Formation. Rev Cubana Oftalmol [online]. 2022, vol.35, n.4 Epub 01-Dic-2022. ISSN 1561-3070.
The human eye is highly exposed to light of all types of electromagnetic waves, the metabolic stress in the elimination of cellular damage, as well as its accumulation, constitute the major oxidative stress due to ultraviolet radiation. The objective was to document the new scientific evidence in epigenetics regarding ultraviolet radiation and oxidative stress in cataract formation. A review of the literature from May 1, 2021 to May 1, 2022 was performed with meta-search engines in English and Spanish. Cumulative biochemical damage at the histone level is considered the primary environmental insult in cataract formation. The immunomodulatory potential of human lens epithelium cells is a promising therapeutic target, due to being the main cell line affected in ultraviolet radiation. The technological, biochemical and physiological advance will allow promoting a different solution, by a different concept of surgery, for the cure of the most prevalent condition in the world for reversible blindness: cataract.
Palabras clave : epigenetics; ultraviolet radiation; oxidative stress; cataract; REDOX.