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Correo Científico Médico
versión On-line ISSN 1560-4381
Resumen
CABRERA RODRIGUEZ, Luis Enrique et al. In vitro effectiveness of amikacin and fosfomicin in uropathogenic and multidrug resistant Escherichia coli strains. ccm [online]. 2019, vol.23, n.4, pp. 1088-1104. Epub 01-Dic-2019. ISSN 1560-4381.
Introduction:
the urinary tract infections acquired in the community caused by multidrug resistant Escherichia coli strains , are a growing phenomenon in the world.
Objective:
to determine the antimicrobial susceptibility, the resistance patterns and to find out the amikacin and fosfomycin sensitivity of the isolated multidrug resistant strains.
Methods:
we developed a descriptive retrospective study in the period from June 1st , 2017 to December 31st , 2018. The universe we worked with was formed by 265 isolated Escherichia coli strains of ambulatory patients, with suspected urinary tract infections, who belonged to two health institutions: Aleida Fernandez Chardiet Hospital and the Municipal Hygiene, Epidemiology and Microbiology Center, in Güines Municipality, Mayabeque Province, Cuba.
Results:
amikacin, fosfomicin and nitrofurantoin presented over 90 % of effectiveness. Antimicrobial resistance of isolated Escherichia coli was most common to ceftazidime (72%), followed by trimethoprim - sulfamethoxazole (61.5%), nalidixic acid (61.1%) and ciprofloxacin (52.8%). The strains showed a resistance pattern from three to nine antibiotics. Nalidixic acid and trimethoprim - sulfamethoxazole were found in most of the multiresistance patterns. Notice that in some profiles, ciprofloxacin has been also included. From the 265 isolated strains of Escherichia coli , 147 (55.4%) were multidrug resistant; and from those, 87% showed higher sensitivity to fosfomycin and amikacin .
Conclusions:
trimethoprim - sulfamethoxazole and quinolones have a high resistance percentage.Fosfomycin and amikacin can be considered suitable therapeutic options for Escherichia coli multidrug resistant strains, based on the sensitivity studied.The results obtained from this study are a reason for epidemiological concern, and require a strict follow-up in the coming years.
Palabras clave : urinary tract infections; Escherichia coli; multiresistant patterns; multidrug resistant; fosfomycin; amikacin (source: MeSH NLM).