Mi SciELO
Servicios Personalizados
Articulo
Indicadores
- Citado por SciELO
Links relacionados
- Similares en SciELO
Compartir
Revista Habanera de Ciencias Médicas
versión On-line ISSN 1729-519X
Resumen
MARTINEZ TELLEZ, Goitybell; TORRES RIVES, Barbara y SANCHEZ RODRIGUEZ, Vicky. Antineutrophil cytoplasmic autoantibodies and clinical activity in Cuban patients with rheumatoid arthritis. Rev haban cienc méd [online]. 2021, vol.20, n.5 Epub 10-Oct-2021. ISSN 1729-519X.
Introduction:
Antibodies against neutrophil cytoplasm are normally detected in patients with vasculitis. Although these antibodies can be present in a wide number of diseases associated with inflammatory and autoimmune conditions such as rheumatoid arthritis, their clinical significance has not been demonstrated.
Objective:
To evaluate the usefulness of different antigenic specificities of antibodies against neutrophil cytoplasm to measure the clinical activity in Cuban patients with rheumatoid arthritis.
Material and Methods:
A cross-sectional study was conducted on 77 Cuban patients with rheumatoid arthritis. Erythrocyte sedimentation rate, C-reactive protein, the clinical indicator of disease activity, anti-citrullinated protein antibodies, rheumatoid factor, and antibodies against neutrophil cytoplasm against different specificities were determined.
Results:
The largest number of patients with elevated disease activity (> 5.1) belonged to the group of antibodies against neutrophil cytoplasm positive patients (p=0.0364). Patients with anti-lactoferrin antibodies had higher disease activity values (p=0.0304). Through multivariate analysis, the influence of positive anti-lysozyme antibodies (p=0.0391), of double positivity of anti-citrullinated protein and anti-lactoferrin antibodies (p=0.0282), as well as that of double positivity of anti-citrullinated protein and anti-elastin antibodies (p=0.0182) on disease activity were demonstrated.
Conclusion:
The antibodies against neutrophil cytoplasm that recognize the antigenic specificities of lysozyme, lactoferrin and elastin are related to higher clinical activity in patients with rheumatoid arthritis.
Palabras clave : Antibodies against neutrophil cytoplasm; rheumatoid arthritis; clinical activity.