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Revista Cubana de Hematología, Inmunología y Hemoterapia
versión On-line ISSN 1561-2996
Resumen
REYES CEPERO, Yudania et al. C-reactive protein as predictor of gravity in patients with COVID-19. Rev Cubana Hematol Inmunol Hemoter [online]. 2024, vol.40 Epub 10-Jun-2024. ISSN 1561-2996.
Introduction:
Several studies have reported that severe COVID-19 is associated with higher levels of C reactive protein than mild disease; however, there are controversy in the results.
Objective:
To determine whether C-reactive protein is a biomarker of severity in patients with COVID-19.
Methods:
A retrospective and descriptive study was carried out on 148 inpatients at Camilo Cienfuegos Hospital, in Sancti Spíritus. The variable analyzed was C-reactive protein. The mean between groups: severe and non-severe, was compared using t Student test for independent samples with a significance level of 0.05. Predictive capacity of the biomarker by ROC curve analysis was determined. Diagnostic accuracy was evaluated.
Results:
The mean value of C-reactive protein in the severe an non severe groups was 106.73 (88.43-125.03) and 26.87 (23.51-30.23), respectively; with highly significant differences. The area under the ROC curve was 0.991(0.975-1.000). The highest sensitivity and the lowest rate of false positive to discriminate between both groups was found at 47.1 mg/L.
Conclusions:
The severity predictive capacity of the test was excellent. The optimal cut-off point to define when a patient was likely to progress to severity was 47.1 mg/L. The quantification of this biochemical parameter could optimize diagnostic and therapeutic strategies.
Palabras clave : C-reactive protein; COVID-19; biomarkers.