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Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
Resumen
MARTINEZ ALVAREZ, Luis y GARCIGA, María Rosa. Incompatibilidad química y estabilidad térmica del baclofeno por análisis térmico. Rev Cubana Farm [online]. 1998, vol.32, n.1, pp. 34-39. ISSN 1561-2988.
A study of the possible chemical interactions between baclofen, active principle, and the different excipients preselected in the preformulation of baclofen tablet was conducted. A study of thermic stability by using the differential scanning calorimetry, which was complemented with thin layer chromatography and infrared spectroscopy, was carried out at the same time. As a result, the non-chemical interaction between the active principle and the excipients was obtained, and an order of thermic stability was established aimed at making possible substitutions of some excipients in the preformulation in order to guarantees a greater stability of the final product.
Palabras clave : DRUG INCOMPATIBILITY; DRUG STABILITY; CHEMISTRY, PHARMACEUTICAL; BACLOFEN [analysis]; TABLETS [analysis]; CHROMATOGRAPHY, THIN LAYER; CALORIMETRY; DIFFERENTIAL SCANNING; SPECTROPHOTOMETRY, INFRARED.