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Revista Cubana de Medicina
versión On-line ISSN 1561-302X
Resumen
GONZALEZ GARCIA, Verónica Marlene; FERNANDEZ MACHIN, Luis Manuel; RUIBAL LEON, Antonio J. y DURAN TORRES, Gilberto. Inhibidores de la enzima conversora de angiotensina: Revisión de estudios multicéntricos. Rev cubana med [online]. 2002, vol.41, n.5, pp. 274-282. ISSN 1561-302X.
A literature review of the angiotensin inhibitors was made. A brief historical review was made and the mechanisms of actions, the effects at different levels and the secondary reactions of these inhibitors were reviewed. Different multicenter studies that have been carried out with this group of drugs were analyzed, in which we found out that such drugs favorably affect morbidity and mortality of patients with heart failure, their effects are higher in those patients with advanced degree of heart failure and that high doses should be used according to tolerance. Although it is said that these inhibitors are not exchangeable, the reviewed literature did not show the superiority of one drug over the others for certain disease and/or group of patients.
Palabras clave : ANGIOTENSIN-CONVERTING ENZYME INHIBITORS [history]; MULTICENTER STUDIES; INDICATORS OF MORBIDITY AND MORTALITY; CARDIOVASCULAR DISEASES [drug therapy].