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Revista Cubana de Medicina Militar
versión On-line ISSN 1561-3046
Resumen
THANH VAN, Phan Nguyen et al. Serum free light-chain concentration and relationship with some characteristics of patients with multiple myeloma. Rev. cuban. med. mil. [online]. 2023, vol.52, n.1 Epub 01-Mar-2023. ISSN 1561-3046.
Introduction:
Quantifying serum free light-chain is a valuable test to determine the risk at the time of diagnosis, assess the response to treatment, and monitor the recurrence of multiple myeloma.
Objective:
To investigate the characteristics of serum free light-chain concentration and its relationship with some clinical and subclinical characteristics in patients with multiple myeloma.
Methods:
Descriptive, retrospective, non-controlled study was conducted, in 74 patients with multiple myeloma. All patients were completed with quantitative tests serum free light-chain κ, and serum free light-chain λ.
Results:
Intact immunoglobulin multiple myeloma accounted for most patients (81%). Most patients had abnormal serum free light-chain at the time of diagnosis (98.6%). High serum free light-chain concentration was correlated with M protein concentration > 3 g/dL (p< 0.05) and there was no statistically significant correlation between high serum free light-chain and other clinical and subclinical features.
Conclusion:
Most patients with multiple myeloma have an elevated serum free light-chain at admission time. Correlation of high serum free light-chain with increased serum M protein was noted.
Palabras clave : multiple myeloma; sFLC concentration; sFLCκ; sFLCλ.