Resumen

PERCEDO, María Irian et al. Field evaluation of protein subunit2 vaccine candidate against classical swine fever. Rev Salud Anim. [online]. 2015, vol.37, n.3, pp. 143-151. ISSN 2224-4700.

The Classical Swine Fever (CSF), also recognized as hog cholera, is among the diseases with high transboundary spreading potential and economic impact for swine breeders of all the sectors. Despite the efforts for its control since its re-emergence in 1993, the disease endemic behavior observed motivated development of a protein subunit E2 vaccine candidate (VE2) to support the disease eradication, in view of the easy differentiation of infected from vaccinated pigs. After successful preclinical assays, the VE2 efficacy was evaluated in a herd of complete productive cycle with more than 5 000 pigs under routine vaccination with a live attenuated vaccine (Chinese Strain), but with reports of sporadic outbreaks of the disease. Monitoring of the serological response was carried out by the neutralization peroxidase-linked assay (NPLA) in different phases of the productive cycle of three animal groups (serum profiles), from litter to fattener, at 12 weeks interval for one year. High percentages of positive animals with titters considered as protective (³ 1:100) were observed, supporting a satisfactory humoral response at population level. Likewise, the fatteners positive to the Direct Immunoperoxidase (DIP) in tonsils decreased at the slaughterhouse during the study period. The favorable evolution of herd health status after VE2 vaccination led to higher productive levels. The preliminary results obtained favorably support the VE2 performance in field conditions, despite the challenge of the virus circulation favored by the disease endemic condition and other pathogen presence

Palabras clave : pigs; Classical Swine Fever; vaccine candidate; E2 glycoprotein.

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