Resumen

GONZALEZ-OTERO, Alejandro et al. Results of the treatment of child Acute Lymphoid Leukemia in Cuba. Rev Cubana Hematol Inmunol Hemoter [online]. 2014, vol.30, n.1, pp. 36-46. ISSN 0864-0289.

Introduction: Acute lymphoid leukaemia (ALL) is the most frequent malignant disease in childhood and the first one to be treated with a common protocol in Cuba. Different protocols have been used and at present there are 10 health centers in Cuba treating children with ALL. Objective: To present the results achieved in the treatment of ALL from 2002 to 2008 with protocol ALLIC (Acute Lymphoblastic Leukemia Intercontinental). Methods: 166 children under 18 years old at the beginning of the disease were treated. Different criteria were used to make prognostic groups which included age and leukocyte counts in the peripheral smear at diagnosis, DNA molecular rearrangements and response to therapy. Results: Event free survival (EFS) after 4 years for the whole group was 69 % and overall survival (SV) was 78 %. EFS in the different prognostic groups were 85 % for standard risk patients, 77 % for the intermediate risk group and 59 % for high risk children. Percentage of initial remission in our patients was lower than the one obtained for the whole group. The majority of early deaths occurred at the beginning of the protocol application. Bone marrow relapses were the more frequent ones. Central nervous system, testicular or combined relapses were lower than 5 %. DNA rearrangements for bcr/ abl or MLL/AF4 were signs of very bad prognosis. Conclusions: These results, even when susceptible to be better, show an adequate level considering that they were achieved in a developing country.

Palabras clave : Acute lymphoblastic leukemia; prognostic groups; overall survival; event free survival.

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