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Revista Cubana de Investigaciones Biomédicas
versión impresa ISSN 0864-0300
Resumen
HERNANDEZ-MATOS, Yanet; DELGADO ROCHE, Liván y MARTINEZ-SANCHEZ, Gregorio. Difference of redux status between spermatozoa and seminal plasma in young adults. Rev Cubana Invest Bioméd [online]. 2013, vol.32, n.2, pp. 159-170. ISSN 0864-0300.
Background: Reactive oxygen species and oxidative stress play a fundamental role in male infertility. However, these oxidizing species have also been associated with the process of capability of male gametes when they are generated at low levels and in a controlled manner. Currently, redox biomarkers are introduced in the clinical diagnosis of male infertility in the world as a complementary tool to the spermiogram parameters. However, in Cuba, this methodology is not yet extended to health services. Objective: The objective of this study was to characterize the redox status of spermatozoa and seminal fluid of apparently healthy subjects through the identification of a number of biomarkers of oxidative stress. Methods: 40 samples of semen of apparently healthy subjects were analyzed, which were obtained by masturbation without the use of lubricants and with at least 3 days of ejaculatory abstinence. The study included subjects from 20 to 35 years of age, who were apparently healthy according to both laboratory tests and paternity test results. Results: The results showed that there are significant differences (p<0, 05) between the markers evaluated in the seminal fluid and the spermatozoon which suggests the existence of a differentiated redux status between the two compartments. Conclusions: These findings demonstrate the need to evaluate the level of oxidative stress in both sexual cells and the fluid that contains them. It will contribute, with no doubt, to a more effective and comprehensive diagnosis of man's fertility.
Palabras clave : oxygen-reactive species; oxidative stress; spermatozoon; seminal fluid; differenciated redux status.