Resumen

HUGUES HERNANDORENA, Beatriz; RODRIGUEZ GARCIA, Julio César; RODRIGUEZ GONZALEZ, Julio César  y  MARRERO RODRIGUEZ, María Teresa. Laboratory animals in endocrinology. Biomodels of type 2 diabetes mellitus. Rev Cubana Endocrinol [online]. 2002, vol.13, n.2, pp. 0-0. ISSN 1561-2953.

It is known that the animal models used in the research of type 2 diabetes mellitus help to study the pathogenic mechanisms leading to the presentation of this disease, accompanied of severe or moderate hyperglycaemia, glucose intolerance and other metabolic alterations related to it, and give the opportunity to explore new treatments and ways of preventing these morbid clinical pictures. Detailed information is given on the biomodels of type 2 diabetes mellitus based on a bibliographic review made on this topic that included those which are spontaneously originated and the ones obtained in an induced way. The environmental factors influencing on them are explained and the biomodels that may present chronic complications of non-insulin dependent diabetes mellitus are also described. It was concluded that these biomodels contribute to the study of the mechanisms causing this affection and are very useful for researchers in this field of Endocrinology, although they are not an exact reflex of this disease in man.

Palabras clave : DISEASE MODELS ANIMAL; ANIMALS LABORATORY; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; MICE; RATS; MACACA MULATTA.