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Revista Cubana de Angiología y Cirugía Vascular
versión On-line ISSN 1682-0037
Resumen
YANES QUESADA, Marelys et al. Evolution of renal function in patients with diabetic foot ulcer treated with Heberprot-P®. Rev Cubana Angiol Cir Vasc [online]. 2022, vol.23, n.3 Epub 01-Dic-2022. ISSN 1682-0037.
Introduction:
Diabetic foot ulcer represents a complication of diabetes mellitus. Heberprot-P® is a medicine for its treatment, whose active substance is a human growth factor that could be associated with the onset of kidney disease.
Objective:
To describe the evolution of renal function after treatment with Heberprot-P® in patients with diabetic foot ulcer.
Methods: Prospective descriptive study in 90 patients diagnosed with diabetic foot ulcer treated with Heberprot-P®. The variables analyzed were: microalbuminuria, creatinine, uric acid and glomerular filtration, at baseline, 6 months and post-treatment year. Relative frequencies of qualitative variables were determined, and mean and standard deviation of quantitative variables. Friedman test for two independent samples, U Mann Whitney and Chi square independence test were performed.
Results:
The quantitative variables of renal function did not vary significantly. At baseline, the glomerular filtrate was 67.1 ml/min; and at both 6 months and a year, 67.2 ml/min. The mean creatinine at 6 months was 86.2 μmol/L; and after a year, 86.1 μmol/L. Uric acid increased its value from 331.7 mmol/L to 345.6 mmol/L at 6 months; and at 340 mmol/L after a year. Urinary albumin excretion improved significantly during the study.
Conclusions:
Patients with diabetic foot ulcer treated with Heberprot-P® showed no impairment of renal function during the first year of treatment. Urinary albumin excretion improved and the rest of the variables remained stable.
Palabras clave : diabetic foot; diabetic kidney disease; Heberprot-P®.