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Revista Habanera de Ciencias Médicas
versión On-line ISSN 1729-519X
Resumen
FERNANDEZ ROMERO, Tammy et al. Protective effect of NeuroEPO on the reproduction of diabetic rats. Rev haban cienc méd [online]. 2022, vol.21, n.4 Epub 10-Ago-2022. ISSN 1729-519X.
Introduction:
Pregestational diabetes constitutes a reproductive risk which requires new treatment strategies. NeuroEPO, a variant of the recombinant human erythropoietin produced in Cuba, has neuroprotective and hypoglycemic effects which can be considered for the treatment of this entity.
Objective:
To evaluate the protective effect of NeuroEPO on the reproduction of diabetic rats.
Material and Methods:
Four groups of adult female Wistar rats with streptozotocin-induced diabetes were used. During pregnancy, one group received the vehicle and the rest of the groups received different doses of NeuroEPO (0,5 mg/kg, 0,75 mg/kg, and 1 mg/kg) subcutaneously, on alternate days, for a total of six applications. A group of non-diabetic rats was used as a control group. Glycemia and reproductive variables were evaluated. For comparisons, Analysis of Variance and Fisher's Exact Test were used. There were significant differences with p-values less than 0,05.
Results:
The group with vehicle presented maintained hyperglycemia, fewer implantations, and embryos, and increased gestational losses. In the group receiving 0,5 mg/kg of NeuroEPO, glycemia decreased significantly and the results of the reproductive variables were similar to the group of non-diabetic rats. With higher doses of NeuroEPO, gestational losses were increased. No congenital malformations were identified in either group.
Conclusions:
The repeated administration of 0,5 mg/kg of NeuroEPO has a beneficial effect on the reproduction of diabetic rats, which may be associated with the reduction of hyperglycemia. Other cytoprotective mechanisms of NeuroEPO should be evaluated in future studies.
Palabras clave : pre-gestational diabetes; streptozotocin-induced diabetes; NeuroEPO; reproduction; reproductive variables in rats.