Resumen

SANTAMARIA ACOSTA, Christian Alexander; WONG VASQUEZ, Lester  y  LABRADA GONZALEZ, Elsy. Characterization of patients with Human Immunodeficiency Virus positive for meningeal cryptococcosis diagnosed by cerebrospinal fluid study at Regional Teaching Hospital of Ambato. Rev Ciencias Médicas [online]. 2023, vol.27, suppl.1  Epub 01-Jul-2023. ISSN 1561-3194.

ABSTRACT Introduction: Human Immunodeficiency Virus is a global health problem, which leads to the development of opportunistic infections in patients. Objective: to characterize patients with Human Immunodeficiency Virus positive for meningeal cryptococcosis. Methods: observational, descriptive, cross-sectional study in patients with Human Immunodeficiency Virus positive to meningeal cryptococcosis diagnosed by cerebrospinal fluid study in the Regional Teaching Hospital of Ambato in the period 2018-2021. The sample (n=155) was selected by simple random sampling. Results: male sex (78,7 %) and ages between 31 and 40 years (36,1 %) predominated; the main symptomatology was headache (69 %), fever (42,6 %) and nausea (31 %). 22,6 % of the patients were not adherent to antiretrovirals, 23,2 % had CD4 count < 500/mm3 and 43,9 % were drug users. Of the patients, 51,6 % had values higher than 100 mg/ dL protein, 51 % had values lower than 29 mg/ dL glucose in cerebrospinal fluid. Protein alterations were associated with CD4 levels (p<0.01) and viral load (p<0,05). Conclusions: patients with Human Immunodeficiency Virus of male sex, aged between the third and fourth decade of life, who do not adhere to antiretroviral therapy and/or consume drugs are prone to the development of meningeal cryptococcosis. Cytochemical analysis of cerebrospinal fluid is useful as a biomarker of unfavorable prognosis in patients with meningeal cryptococcosis.

Palabras clave : VIH; CRYPTOCOCCOSIS; CEREBROSPINAL FLUID; OPPORTUNISTIC INFECTIONS; BIOMARKERS.

        · resumen en Español     · texto en Español | Inglés     · Español ( pdf )