Introduction:

squamous cell carcinoma (SCC) is the most common cancer in the oral cavity, it represents 5 % of all neoplasms and occupies number 12 of all malignant neoplasms, there is a relationship between the cervix, oral cavity and oropharynx.

Objective:

to argue the relationship between human papillomavirus (HPV) infection and oral squamous cell carcinomas.

Methods:

a systematic literature review was performed, 60 articles indexed in (Pubmed, Scopus, Cochrane Library, Google Scholar and SciELO) were reviewed. Only bibliographic and systematic reviews with less than 10 years of publication, based on human studies, published in English or Spanish and with the text available were included. All those studies that did not meet these parameters were excluded, leaving a total of 16 results.

Development:

squamous cell carcinoma represents 90 % of malignant neoplasms of the oral cavity and oropharynx. There are several HPV types among them 201 types that differ due to variations in the L1 DNA sequence. The literature deduces that 17,8 % of all cancers are stimulated by contagious type agents and 12,1 % belong to viruses, this forces to inquire more about HPV as a carcinogenic agent and its contribution in squamous cell carcinoma (SCC) in oral cavity and oropharynx.

Conclusions:

the carcinogenic mechanisms used by HPV for cell transformation are through E6 and E7 proteins as responsible for the malignization process.

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