SciELO - Scientific Electronic Library Online

 
vol.32 número2Formulación y estudio de estabilidad de acetilcolina 20 mg, liofilizado para solución oftálmica índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Farmacia

versión On-line ISSN 1561-2988

Resumen

PEREZ BLANCO, María Elena  y  GARCIA VALDES, Jesús. Mejoramiento del proceso de obtención de citrato de piperacina. Rev Cubana Farm [online]. 1998, vol.32, n.2, pp. 81-87. ISSN 1561-2988.

It is described the industrial procedure by which the piperazine citrate of pharmaceutical quality was obtained on making react at 60 oC an anhydrous piperazine solution with another solution of monohydrated citric acid. The mixed solution was subjected to a treatment with coal, filtration while hot, crystallization and purification. The adequate concentration for crystallization was determined, the concentration control was introduced by using the refractometric reading as a process control, and the charge used in the preparation of the lot when the mother liquids colleted in the previous lot were used was modified. The results of the accumulated yield were analyzed as the number of reproductions increased. Data obtained in the assays at the level of experimental production were included. It was concluded that the procedure is adequate for the obtention of piperazine citrate according to its economic and technical feasibility.

Palabras clave : PIPE RAZINES; DRUG INDUSTRY; CHEMISTRY; PHARMACEUTICAL; DRUG QUALITY; REFRACTOMETRY; CRYSTALLIZATION; DRUG STABILITY.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License