Mi SciELO
Servicios Personalizados
Articulo
Indicadores
- Citado por SciELO
Links relacionados
- Similares en SciELO
Compartir
Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
Resumen
GARCIA PENA, Caridad M. et al. Analytical method by high resolution-liquid chromatography for assay of 2 mg Clonazepam tablets disolution without lactose. Rev Cubana Farm [online]. 2007, vol.41, n.2, pp. 0-0. ISSN 1561-2988.
A valid method was developed to assess 2 mg Clonazepam tablets disolution without lactose by high-performance liquid chromatography by UV detection to 254 nm. Establishment of Clonazepam in dissolution medium was confirmed, and parameters of specificity, linearity, and accuracy were assessed, as well as influence of filtration and stability or active principle. Linearity curve was drawed in rank of 1, 2-2,6 mg/mL, with a correlation coefficient similar to 0,99418; statistical test wasn’t statistically significant for interceptor and slope. In study, it was possible to demonstrate that stability or active principle in dissolution was maintained in more than double of duration of dissolution assay.
Palabras clave : Clonazepam; valaidation; dissolution assay.