Resumen

BRENA BETANCOURT, Giselle et al. COMPARATIVE STUDY OF THE EFFECTS OF THE ACTIVE INGREDIENT BEESWAX ALCOHOLS AND THEIR PHARMACEUTICAL FORMULATIONS ON ETHANOL-INDUCED GASTRIC ULCER IN RATS. Rev. CENIC Cienc. Biol [online]. 2023, vol.54, pp. 287-294.  Epub 25-Dic-2023. ISSN 2221-2450.

Peptic ulcer is a very common chronic relapsing disease of the gastrointestinal tract, whose main complications (bleeding, perforation, penetration and obstruction) affect the quality of life of patients and can lead to death. The drugs used for its treatment produce adverse effects that limit their medical prescription. The mixture of alcohols obtained from beeswax, registered in the form of tablets as Abexol®, exerts gastroprotective effects demonstrated in preclinical and clinical studies. The aim of this work was to compare the effects of the active ingredient-beeswax alcohols (BWA-AI) and its formulations in form of BWA-tablets and BWA-suspension on ethanol- induced gastric ulcer in rats. The animals were distributed in nine groups: a control without damage and eight groups in which the ulcer was induced by ethanol: a positive control (with damage), one with omeprazole-reference substance-(20 mg/kg), and six treated with BWA-AI, BWA-tablets and BWA-suspension, respectively, at doses of 25 and 200 mg/kg. All treatments significantly reduced the ulcer index with respect to the positive control, although BWA-suspension produced the greatest reduction, without differences being observed between them on the content of mucus, malondialdehyde and total proteins in the gastric mucosa. In conclusion, BWA-suspension exerts an effect superior to that of BWA-tablets and BWA-AI, at the same doses, on gastric ulcer induced by ethanol in rats.

Palabras clave : Beeswax alcohols; Abexol; suspension; gastric ulcer; ethanol, rats.

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