Resumo

RAMOS PICOS, Diana; GOMEZ CARRIL, Martha  e  FERNANDEZ MENA, Dianelis. Métodos de obtención de microesferas biodegradables. Rev Cubana Farm [online]. 2001, vol.35, n.2, pp. 126-135. ISSN 1561-2988.

The controlled release of therapeutic agents from polymeric biodegradable microspheres has been widely studied. Polylactic acid and its copolymers with glycolic acid have been used in the preparation of microspheres because of their biodegradability and biocompatibility. These microspheres have been prepared by various methods which are reviewed in this paper. As to their most used solvent evaporation-extraction method. The variables that might affect it are set forth here and some of them are also discussed.

Palavras-chave : MICROSPHERES; POLYMERS; POLYGHANTINGIO; TECHNOLOGY, PHARMACEUTICAL; BIODEGRADATION; DRUG COMPOUNDING..

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