Resumo

DIAZ MOLINA, Milena; PEREZ SAAD, Héctor; BU WONG, Margarita  e  SANCHEZ RODRIGUEZ, Nora. Neuropharmachological characterization of 2-phenyl-4, 4-bis-(hydroxymethyl)-2-oxazoline obtained under microwaves irradiation. Rev Cubana Farm [online]. 2004, vol.38, n.3, pp. 1-1. ISSN 1561-2988.

Some aryl-oxazolines have been described as active substances on the central nervous system with diverse effects and applications as depressants, anesthetics, anticonvulsants, etc. In the present paper, the primary neuropharmacological characterization of 2-phenyl-4, 4-bis-(hydroxymethyl)-2-oxazoline, obtained by a method of synthesis under microwaves irradiation as an energy source, was made. The application of Irwin's test showed that this compound has a depressive effect on the central nervous system, with a marked inhibition of the motor activity and muscular tone and with loss of postural reflexes. At moderate doses, these effects were accompanied with signs of central excitation. These characteristics suggested an action of peripheral type, confirmed by the blocking effect of the contorsions in the peritoneal irritation test caused by acetic acid 0.8 % and the reduction of the potential amplitude of the composed neuromuscular action during the supramaximal stimulation of the cyatic nerve, tests that evidenced a local anesthetic action for 2-phenyl-4, 4-bis-(hydroxymethyl)-2-oxazoline.

Palavras-chave : 2-phenyl-4; 4-bis-(hydroxymethyl)-2-oxazoline; local anesthesia; composed muscular action potential (CMAP).