Resumo

VAZQUEZ VIGOA, Alfredo; CRUZ ALVAREZ, Nélida; GONZALEZ DEL VALLE, Zulema  e  VAZQUEZ CRUZ, Alfredo. Antagonistas de los receptores de angiotensina II. Rev cubana med [online]. 1998, vol.37, n.2, pp. 83-92. ISSN 1561-302X.

The purpose of this paper was to review the new knowledge about angiotensin II receptors as well as the clinical and therapeutic implications resulting from their pharmacological block. It was stressed the great importance of the renin-angiotensin system in the cardiovascular and renal regulation and it was also explained that its effects are measured by the action of AII on its receptors (type 1 and type 2). It was concluded that the recent advances achieved in the pharmacological control of that system, specially due to the appearance of new orally active angiotensin II receptor antagonists, such as losartan, may be extraordinarily efficient in the treatment of arterial hypertension and heart failure, and may prevent the progression of chronic kidney failure.

Palavras-chave : RENIN-ANGIOTENSIN SYSTEM; RECEPTORS, ANGIOTENSIN [pharmacology]; RECEPTORS, ANGIOTENSIN [therapeutic use]; ANGIOTENSIN II [pharmacology]; ANGIOTENSIN LL [therapeutic use]; HYPERTENSION [drug therapy]; KIDNEY FAILURE [drug therapy]; HEART FAILURE, CONGESTIVE [drug therapy].

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