Resumo

FERNANDEZ-ORTEGA, Celia; RAMIREZ-SUAREZ, Anna; PANEQUE-GUERRERO, Taimí  e  CASILLAS-CASANOVA, Dionne. Notes on HIV pathogenesis, therapy and eradication. Biotecnol Apl [online]. 2012, vol.29, n.4, pp. 266-269. ISSN 1027-2852.

This report summarizes the main topics delivered as lectures at the meeting Frontiers in HIV pathogenesis, Therapy and Eradication, held at the Whistler Conference Centre, in Whistler British Columbia, Canada, in March 26-31. The meeting was organized as part of the Keystone Symposia on Molecular and Cell Biology joined with the conference Cell Biology of Virus Entry. The current status on research for eradicating HIV-1 latent reservoirs and ways to reactivate them for destruction with current or novel antiretroviral therapies were the key topics. Targeted inhibition of virus entry, new classes of inhibitors, animal models for testing antiretroviral therapies and virus cell-to-cell contact-mediated transmission, together with structural analysis of HIV-1 proteins and replication processes, were also presented. The useful discussions at both the oral and poster sessions paved the way for understanding processes essential for future therapeutic attempts to effectively inhibit virus replication and transmission, including its eradication.

Palavras-chave : HIV-1; antiretroviral therapy; viral latency; viral entry; HIV persistence.

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