Resumo

PICO BERGANTINOS, María Victoria; RUIZ GONZALEZ, Marlen; PICO BERGANTINOS, Thais  e  GARCIA PEREZ, Miguel. El papel del músculo liso bronquial y los nervios en la fisiopatología del asma bronquial. Rev Cubana Med Gen Integr [online]. 2001, vol.17, n.1, pp. 81-90. ISSN 1561-3038.

The great deal of evidence that has been collected for the last years in connection with the inflammatory nature of bronchial asthma have led us to make an obliged review of some important aspects of its physiopathology. Among these aspects, we consider it is very interesting the role played by the airway smooth muscle and nerves in the genesis and development of this disease. The protein kinase C (PKC) is involved in the maintained contraction of the airway smooth muscle in vitro and it may be of particular significance in patients with chronic asthma. The thickening of the airway smooth muscle is another characteristic of some patients with asthma and it may occur in the proximal parts and in the distal parts of the airways. Cough and chest "squeeze" are common symptoms in asthma and these symptoms are probably mediated by the activation of afferent nerves. Finally, the possible future questions that may define the research in the field of asthma physiopathology as regards the airway smooth muscle and pulmonary innervation are expressed

Palavras-chave : ASTHMA [complications]; ASTHMA [physiopathology]; MUSCLE, SMOOTH [innervation].

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