Resumo

GARCIA TRIANA, Bárbara E.; VICEDO TOMEY,, Agustín; GARCIA PINEIRO, José C  e  SALDANA BERNABEU, Alberto. Enzimas proteolíticas relacionadas con la enfermedad periodontal inflamatoria. Rev Cubana Estomatol [online]. 1998, vol.35, n.2, pp. 62-67. ISSN 1561-297X.

The periodontal disease brings about the destruction of the protective and supporting tissues of the teeth, therefore, the role of enzymes capable of degrading connective tissue matrix is of great importance. There are evidences of the possible involvement of the matrix metalloproteinases, leukocyte proteases and bacterial proteases in the pathogenesis of such disease. Their action is controlled by specific inhibitors in the tissues. This means that any protease-inhibitor imbalance favouring the presence of proteases may lead to the destruction of matrix connective tissue. In turn, proteolytic activity is influenced by different factors that globally induce a degradative or formative phenotype, and thus, may be involved in the pathogenesis of the periodontal disease.

Palavras-chave : PERIODONTITIS [enzymology]; PEPTIDE HYDROLASES [metabolism]; PERIODONTITIS [etiology].

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