Resumo

REYES TUR, María Isabel  e  TROCHE CONCEPCION, Yenilen. Use of bisphosponates in bone-related diseases. Rev Cubana Farm [online]. 2012, vol.46, n.4, pp. 457-469. ISSN 0034-7515.

Bisphosphonates are drugs that help to fortify bones, reduce the risk of fractures and relieve pain in those patients who suffered metastatic cancer. These drugs generally decrease bone reabsorption when orally administered; they are also intravenously used as coadjuvant to treat certain types of cancer, hence, it is necessary to take into account the adverse effects associated to their use. This paper presented a literature review about this group of drugs for the treatment of bone-related diseases, to this end, some available databases in Google, Scirus and Medline for the last 10 years were used. It was concluded that bisphosphonates inhibit osteoclast-mediated bone reabsorption, and based on this mechanism of action, they are prescribed for the treatment of osteoporosis.

Palavras-chave : bisphosphonates; bone-related diseases; bone reabsorption.

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