Resumo

GONZALEZ SOTOLONGO, Odalys et al. Fatal idiosyncratic reaction to propylthiouracilo. Rev Cub Med Mil [online]. 2008, vol.37, n.4, pp. 0-0. ISSN 1561-3046.

The case of a patient with hyperthyroidism due to an autoimmune disease of the thyroid glands that after two weeks of treatment with propylthiouracil presented a systemic rash accompanied with fever evolving quickly to an acute hepatic failure, multiorgan failure, and death, was presenetd. A massive liver necrosis was confirmed in the necropsy. The hepatic affectations induced by idiosyncratic drug reaction were reviewed. We suggest to instruct these patients on the possible symptoms of hepatotoxicity, to indicate periodical hepatic tests to hyperthyroid patients treated with antithyroid agents, and to avoid the simultaneous use of phenobarbital.

Palavras-chave : Acute hepatic failure; idiosyncratic reaction.

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