Resumo

AQUINO ROJAS, Suharmi; SOLER NODA, Gilberto  e  BENCOMO HERNANDEZ, Antonio. Platelet refractoriness: approaches to diagnostic. Rev Cubana Hematol Inmunol Hemoter [online]. 2017, vol.33, n.4, pp. 4-14. ISSN 1561-2996.

Platelet refractoriness represent a significant clinical problem that complicates the provision of platelet transfusions, it is associated with adverse clinical outcomes and increases health care costs. Platelet refractoriness is defined as an inadequate response to platelet transfusions after two sequential transfusions. Nonimmune causes are the most likely and the first that should be explored in the diagnosis of platelet refractoriness. Immune-mediated platelet refractoriness is cause by antibodies to human leukocyte antigens (HLAs) and/or human platelet antigens. If antibodies are identified, there are 3 strategies for identifying compatible platelet units: HLA matching, crossmatching, and antibody specificity prediction. It is recommended to use fresh and ABO-matched platelets in the diagnosis of platelet refractoriness to eliminate these potential variables as causes of refractoriness.

Palavras-chave : platelet refractoriness; alloimmunization; thrombocytopenia; platelets transfusion; HLA; HPA.

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