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Revista Cubana de Hematología, Inmunología y Hemoterapia
versão On-line ISSN 1561-2996
Resumo
QUINTERO SIERRA, Yamilé et al. Characterization of adult patients with diffuse large B-cell non-Hodgkin lymphoma. Rev Cubana Hematol Inmunol Hemoter [online]. 2020, vol.36, n.4 Epub 01-Dez-2020. ISSN 1561-2996.
Introduction:
Diffuse large B-cell lymphoma is the most common subtype of aggressive non-Hodgkin lymphoma.
Objective:
Characterize the behavior of adult patients with diffuse large B-cell lymphoma.
Methods:
An observational retrospective longitudinal descriptive study was conducted of 56 adult patients with diffuse large B-cell lymphoma attending the Institute of Hematology and Immunology from January 1998 to December 2018.
Results:
Of the patients studied, 55.4% were male, and a predominance was found of white skin color (76.8%) and the 59-78 years age group (44.6%). Patients with comorbidities prevailed, mainly hypertension (35.7%) with an ability to perform activities of daily living (55.4%). 53.6% of the patients were in stage IV at diagnosis. Patients with type B symptoms prevailed with 85.7%, and the low to intermediate risk group was the most common with 35.7%. The regimen most frequently used was R-CHOP, obtaining 85.7% complete remission. 17.9% of the patients died and 41.1% relapsed. Overall survival at 3, 5 and 10 years was 87.0%, 83.0% and 80.0%, respectively. Disease-free survival at 3, 5 and 10 years was 74.0%, 67% and 56%, respectively.
Conclusions:
Overall and disease-free survival were high.
Palavras-chave : diffuse large B-cell lymphoma; overall survival; disease-free survival.