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Revista Cubana de Hematología, Inmunología y Hemoterapia
versão On-line ISSN 1561-2996
Resumo
CASTRO URIOL, Denisse Angélica; TARAZONA LOPEZ, Deisy Shudey; MENDOZA CHOQUE, Ronald e BELTRAN GARATE, Brady Ernesto. CD5 positive Diffuse large B cell lymphoma with prostate involvement: An unusual recurrence. Rev Cubana Hematol Inmunol Hemoter [online]. 2021, vol.37, n.4 Epub 01-Dez-2021. ISSN 1561-2996.
Introduction:
CD5 positive Large B-cell Lymphoma (CD5 + DLBCL) constitutes a rare and aggressive pathology with poor response to chemoimmunotherapy.
Objective:
To describe a case with a diagnosis of CD5 + DLBCL with an unusual recurrence in the prostate.
Clinical case:
A 61-year-old male presented abdominal pain and B symptoms. Imaging studies showed mediastinal and retroperitoneal lymphadenopathy. The pathology informed a CD5+ DLBCL diagnosis, receiving first-line R-CHOP treatment and achieving complete remission, with prostatic early relapse confirmed by immunohistochemistry. Therefore, he received R-ICE as rescue treatment with poor response and performance status decline.
Conclusions:
CD5 + LDCGB represents a rare and aggressive disease, being the prostate relapse a very unusual event, in which the exhaustive clinical and pathological workup is essential for an accurate diagnosis. To date, the response to standard or higher-intensity therapies is disappointing, so more studies are needed in the future.
Palavras-chave : Lymphoma; Lymphoma Non-Hodgkin; CD5 Antigens; Recurrence; Prostate.