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Revista Cubana de Hematología, Inmunología y Hemoterapia
versão On-line ISSN 1561-2996
Resumo
FUNDORA CEDENO, Maydí; AGRAMONTE LLANES, Olga Margarita e MORALES, Maydelin Miguel. Uric acid in pregnant women diagnosed with sickle cell disease and preeclampsia. Rev Cubana Hematol Inmunol Hemoter [online]. 2022, vol.38, n.1 Epub 14-Abr-2022. ISSN 1561-2996.
Introduction:
Uric acid is the end product of the purine cycle and is essential as a marker of kidney disease, gout and pre-eclampsia. This biomarker has potential effects on the placenta and fetus of a pregnant woman with sickle cell disease.
Objective:
To describe the potential effects of uric acid in pregnant women with sickle cell disease.
Methods:
Literature in English and Spanish was reviewed, through the PubMed website and the academic search engine Google, in articles published in the last five years. The search terms were: pre-eclampsia, uric acid and risks in pregnant women with sickle cell disease. The most relevant aspects of the subject were analyzed in the reviewed bibliography.
Analysis and synthesis of information:
The increase in uric acid added to vasoocclusion, hypoxia and tissue necrosis at the level of the placenta are mechanisms invoked in the development of pre-eclampsia and the rates of premature births they present. It is noteworthy that it does not have a uniform trajectory in all patients, especially a better evolution is observed, with less presence of these complications in those patients who show a more favorable genotype, fetal hemoglobin levels and hemoglobin S haplotype.
Conclusions:
Uric acid constitutes a useful and alarm biomarker in the diagnosis of pre-eclampsia, one of the worst complications both for maternal life and for her offspring, as the pregnant woman with sickle cell disease is a patient at a very high risk of preterm delivery. prematurity, low birth weight, stillbirths and placental infarction.
Palavras-chave : uric acid; preeclampsia; sickle cell disease; hemoglobin S.