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Revista Cubana de Medicina General Integral
versão On-line ISSN 1561-3038
Resumo
CABRERA RODRIGUEZ, Luis Enrique et al. Escherichia coli and Klebsiellap neumoniae multiresistance from patients with urinary tract infection acquired in the community. Rev Cubana Med Gen Integr [online]. 2019, vol.35, n.1 Epub 30-Jul-2019. ISSN 1561-3038.
Introduction:
The increase of bacterial multiresistance constitutes a public health problem at the international level.
Objectives:
To determine antimicrobial sensitivity and multiresistance patterns in strains of Escherichia coli and Klebsiellapneumoniae isolated from urine cultures.
Methods:
A retrospective, descriptive study was conducted at the Municipal Center for Hygiene, Epidemiology and Microbiology, Güines municipality, Mayabeque Province, Cuba, in the period from January to December, 2017. The study included 250 Escherichia coli and 62 Klebsiellapneumoniae strains isolated and identified from urine samples from patients with urinary tract infection acquired in the community. Antimicrobial sensitivity was evaluated with the method of diffusion in agar using Kirby Bauer´s technique.
Results:
In Escherichia coli, resistance levels higher than the 60% were observed in antimicrobial nalidixic acid, cefotaxime, trimethoprim-sulfamethoxazole and ceftazidime. Nitrofurantoin and amikacin presented 88.8% and 83.8% of effectiveness, respectively. High values of resistance to ceftazidime, trimethoprim-sulfamethoxazole and nalidixic acid were present in Klebsiellapneumoniae. Amikacin presented sensitivity levels of 71%. Resistance to third-generation cephalosporins was detected in 78 (31.2%) of Escherichia coli and 26 (41.9%) Klebsiellapneumoniae. From the Escherichia coli and Klebsiellapneumoniae isolates, 143 (57.2%) and 35 (56.4%),respectively, presented multidrug resistance.
Conclusions:
There is circulation of strains which are resistant to third generation cephalosporins and multidrug resistants that cause urinary tract infections acquired in the community and there are reports on antibiotics (nitrofurantoin and amikacin) that might be used to combat them empirically in this geographical area.
Palavras-chave : Urinary tract infection; Escherichia coli; Klebsiellapneumoniae; resistance patterns; multiresistance.